SPRAVATO® (esketamine) Treatment

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat adults with treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. Learn more on the SPRAVATO® website.

SPRAVATO® is approved for the treatment of treatment-resistant depression (TRD) in conjunction with an oral antidepressant. It is also FDA approved for major depressive disorder (MDD) with suicidal thoughts and behavior.

SPRAVATO® works through a novel mechanism of blocking NMDA type of glutamate receptors. It is the only medication approved with this type of mechanism of action. It has shown to be working much faster than traditional antidepressants and help people with treatment resistant depression.

Yes, SPRAVATO® is an adjunctive or add-on treatment which means you add SPRAVATO® to your antidepressant(s) for better results.

There are two phases to treatment.

1. Induction Phase
SPRAVATO® is administered twice a week for 1-4 weeks.
Dosage is 56 or 84 mg each time.

2. Maintenance Phase I
SPRAVATO® is administered once a week from week 5 to Week 9.
Dosage is 56 or 84 mg each time

3. Maintenance Phase II
SPRAVATO® is administered every other week after 9 weeks and up to one year.
Dosage is 56 or 84 mg each time.

Treatment is individualized based on response to treatment. Some people may need more or different schedule. And, some people may need only 1-2 months of treatment

• First, you'll arrive at the office 30 minutes prior to each SPRAVATO® treatment session. Please refrain from eating 2 hours before the sessions and avoid drinking liquids 30 minutes before hand. You can take your regular medications with a sip of water, but it's recommended to hold any benzodiazepine medications (Xanax, Ativan, Klonopin, Valium etc.) on the day of treatment.

• Next, you receive SPRAVATO® through nasal spray administration and are closely monitored by both the provider and trained healthcare professionals for a duration of 2 hours in a safe, calming environment located within our office. Your vital signs are checked periodically throughout the treatment session. Plan to allocate 2 - 3 hours for each visit to the office.

• Patients undergoing SPRAVATO® treatment often report feeling relaxed and comfortable. We encourage patients to follow up with their therapists regularly after SPRAVATO® sessions to facilitate a therapeutic experience.

• Also, you must agree to and follow treatment recommendations. You’ll need a friend or family member to accompany you and drive you home after each treatment session, as it’s advised not to operate heavy machinery or drive on the day of treatment. You will remain in the office until released by the healthcare provider.

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VIDEO: What to expect during your treatment